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PIAS3 polyclonal antibody

货号: BS71897

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS71897

Product Name :PIAS3 polyclonal antibody

Swiss-Prot :Q9Y6X2

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200

Background :This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PIAS3 polyclonal antibody detects endogenous levels of PIAS3 protein.

BiowMW :~ 68 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PIAS3;ZMIZ5

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PIAS3.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PIAS3 expression in rat lung (A), rat spleen (B) whole cell lysates.

Immunohistochemical analysis of PIAS3 staining in human lung cancer formalin fixed paraffin embedded tissue section.

PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis

JournalCell Death & Disease

ApplicationWB

IF5.959

SpeciesHuman

PMID24052079