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Aconitase 1 (ACO1) polyclonal antibody

货号: BS71875
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS71875
Product Name :Aconitase 1 (ACO1) polyclonal antibody
Swiss-Prot :P21399
Host :Rabbit
Reactivity :Human, Mouse, Rat
Applications :WB
Application_all :WB,1:500 - 1:1000
Background :The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Aconitase 1 (ACO1) polyclonal antibody detects endogenous levels of Aconitase 1 (ACO1) protein.
BiowMW :98KDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ACO1;ACONS;HEL60;IREB1;IREBP;IREBP1;IRP1
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Aconitase 1.
Conjugate :Unconjugated
Modification :Unmodified
Western blot analysis of Aconitase 1 expression in Hela (A) whole cell lysates.
  • Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts
    JournalJournal Of Clinical Biochemistry And Nutrition
    ApplicationWB
    IF2.19
    SpeciesRat

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com