中国 EN 400-660-9091

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Leptin Receptor polyclonal antibody

货号: BS7184
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS7184
Product Name :Leptin Receptor polyclonal antibody
Swiss-Prot :P48357
Host :Rabbit
Reactivity :Human, Rat
Applications :WB, IF/ICC
Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200
Background :The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Polyclonal Antibodies
BiowMW :140KDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CD295;LEP-R;LEPRD;OB-R;OBR;LEPR
Immunogen :Recombinant fusion protein of human LEPR(NP_002294.2).
Conjugate :Unconjugated
Modification :Unmodification
Western blot analysis of extracts of various cell lines, using Leptin Receptor antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 180s.
Immunofluorescence analysis of HepG2 cells using Leptin Receptor Rabbit pAb at dilution of 1:50 . Blue: DAPI for nuclear staining.
  • Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression
    JournalBrain Research
    ApplicationWB
    IF2.733
    SpeciesHuman
    PMID
  • Plumbagin Inhibits Leptin-Induced Proliferation of Hepatic Stellate Cells via JAK2-STAT3 Pathway to Protect against Hepatic Fibrosis
    JournalTropical Journal Of Pharmaceutical Research
    ApplicationWB
    IF0.504
    SpeciesHuman
    PMID

关注我们

400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com