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P-glycoprotein 1 polyclonal antibody

货号: BS71461

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS71461

Product Name :P-glycoprotein 1 polyclonal antibody

Swiss-Prot :P08183

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200

Background :The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :P-glycoprotein 1 polyclonal antibody detects endogenous levels of P-glycoprotein 1 protein.

BiowMW :~ 150 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1; P-gp

Immunogen :A synthetic peptide of human P-glycoprotein 1

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using P-glycoprotein 1 antibody.

Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell

JournalJournal Of Agricultural And Food Chemistry

ApplicationWB

IF5.279

SpeciesHuman

PMID29730933