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TPPP/p25 polyclonal antibody

货号: BS71295
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS71295
Product Name :TPPP/p25 polyclonal antibody
Swiss-Prot :O94811
Host :Rabbit
Reactivity :Human, Mouse, Rat
Applications :WB
Application_all :WB,1:500 - 1:1000
Background :Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :TPPP/p25 polyclonal antibody detects endogenous levels of TPPP/p25 protein.
BiowMW :24kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TPPP;TPPP/p25;TPPP1;p24;p25;p25alpha
Immunogen :Recombinant fusion protein of human TPPP/p25(NP_008961.1).
Conjugate :Unconjugated
Modification :Unmodified
Western blot analysis of TPPP/p25 expression in Jurkat (A), mouse brain (B), rat brain (C) whole cell lysates.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com