产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

UVRAG polyclonal antibody

货号: BS71241

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS71241

Product Name :UVRAG polyclonal antibody

Swiss-Prot :Q9P2Y5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background :UVRAG (UV radiation resistance-associated gene), also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :UVRAG polyclonal antibody detects endogenous levels of UVRAG protein.

BiowMW :~ 100 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Autophagy Signaling,

Alternative Name :p63; DHTX; VPS38;

Immunogen :Recombinant protein of human UVRAG.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded human liver injury using UVRAG antibody at dilution of 1:100 (x40 lens).

Immunohistochemistry of paraffin-embedded rat lung using UVRAG antibody at dilution of 1:100 (x40 lens).

Immunohistochemistry of paraffin-embedded mouse lung using UVRAG antibody at dilution of 1:100 (x40 lens).