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MB21D1 polyclonal antibody

货号: BS71168

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS71168

Product Name :MB21D1 polyclonal antibody

Swiss-Prot :Q8N884

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB :1:500~1:2000

Background :cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MB21D1 polyclonal antibody detects endogenous levels of MB21D1 protein.

BiowMW :~ 59 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :STING Signaling,

Alternative Name :cGAS; h-cGAS; C6orf150

Immunogen :A synthetic peptide of human MB21D1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using MB21D1 antibody.

免疫沉淀（IP）

免疫组织化学（IHC）