产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

CD2AP polyclonal antibody

货号: BS70918

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70918

Product Name :CD2AP polyclonal antibody

Swiss-Prot :Q9Y5K6

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB 1:500 - 1:2000

Background :This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD2AP polyclonal antibody detects endogenous levels of CD2AP protein.

BiowMW :~ 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of ECM and Cytoskeletal Factors to EMT,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Alternative Name :CMS; CD2-associated protein; Adapter protein CMS

Immunogen :A synthetic peptide of human CD2AP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cells, using CD2AP antibody.

Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction

JournalFaseb Journal

ApplicationWB

IF5.391

SpeciesMouse

PMID
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS

JournalInternational Journal of Biological Sciences

ApplicationWB

IF6.58

SpeciesHuman

PMID34803506