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LRP6 polyclonal antibody

货号: BS70722

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70722

Product Name :LRP6 polyclonal antibody

Swiss-Prot :O75581

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB: 1:500 - 1:2000

Background :This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LRP6 polyclonal antibody detects endogenous levels of LRP6 protein.

BiowMW :~ 170 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ESC Pluripotency and Differentiation Signaling Pathway,Regulation of Microtubule Dynamics,Translational Contral elF4 and p70 S6 Kinase,Wntβ catenin signaling,MTOR signaling,

Alternative Name :LRP6; ADCAD2; STHAG7

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human LRP6 (NP_002327.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of mouse liver, using LRP6 antibody at 1:1000 dilution.