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UCP1 polyclonal antibody

货号: BS70689

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS70689

Product Name :UCP1 polyclonal antibody

Swiss-Prot :P25874

Host :Rabbit

Reactivity :Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:100

Background :Uncoupling protein 1 (UCP1) is a mitochondrial inner membrane transport protein that is primarily expressed in brown adipose tissue (BAT). UCP1 dissipates the pH gradient resulting from oxidative phosphorylation, which uncouples ATP synthesis from oxidative phosphorylation and leads to the release of heat energy. As a result, UCP1 plays an important role in thermogenesis. Research studies indicate that subcutaneous white adipose depots in mice contain beige adipocytes that express low levels of UCP1 protein. Additional studies show possible differences in thermogenesis in individuals carrying specific polymorphisms in the corresponding UCP1 gene. Related studies link UCP1 to the possible development of obesity and type 2 diabetes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :UCP1 polyclonal antibody detects endogenous levels of UCP1 protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :UCP1; SLC25A7; UCP

Immunogen :A synthetic peptide corresponding to a sequence within amino acids 100-200 of human UCP1 (NP_068605.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using UCP1 antibody at 1:710 dilution.

Immunohistochemistry of paraffin-embedded mouse brown adipose using UCP1 pAb at dilution of 1:50 (40x lens).

Immunohistochemistry of paraffin-embedded rat brown adipose using UCP1 pAb at dilution of 1:50 (40x lens).

Immunofluorescence analysis of mouse brown adipose cells using UCP1 pAb at dilution of 1:50 (40x lens).

Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival

JournalAging Cell

ApplicationIHC

IF7.346

SpeciesMouse

PMID31389140
Rat BAT xenotransplantation recovers the fertility and metabolic health of PCOS mice

JournalJournal Of Endocrinology

ApplicationWB

IF4.286

SpeciesMouse

PMID33295883