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Notch 2 polyclonal antibody

货号: BS7044

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS7044

Product Name :Notch 2 polyclonal antibody

Swiss-Prot :Q04721

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IP:1:100~1:200

Background :Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. Notch2 is a member of the Notch family and mutation in Notch2 is associated with Alagille syndrome.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Notch 2 polyclonal antibody detects endogenous levels of Notch 2 protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Notch Signaling,Contribution of Soluble Factors to EMT,

Alternative Name :Notch 2;Hn2;N2ECD;N2ICD;NOTCH2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Notch 2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Notch 2 expression in HEK293T (A), HepG2 (B) whole cell lysates.

Immunohistochemical analysis of Notch 2 staining in human breast cancer formalin fixed paraffin embedded tissue section.

免疫沉淀（IP）