Product Name :Cleaved-Notch 2 (A1734) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Cleaved-Notch 2 (A1734) polyclonal antibody detects endogenous levels of Notch 2 protein intracellular domain.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Notch Signaling,Contribution of Soluble Factors to EMT,
Alternative Name :Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; Notch 2 intracellular domain; NOTCH2
Immunogen :Synthetic peptide, corresponding to amino acids 1734-1800 of Human Notch 2.
