产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Lamin A (D230) polyclonal antibody（KU）

货号: BS7013

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7013

Product Name :Lamin A (D230) polyclonal antibody（KU）

Swiss-Prot :P02545

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, is comprised of ICE, CPP32, ICH-1/Nedd-2, Tx, Mch2, Mch3 (ICE-LAP3 or CMH-1), Mch4 and ICE-LAP6. Ced-3/ICE family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Lamin C is a splice variant of Lamin A, differing only at the carboxy-terminus. Lamins A and C are identical for the first 566 amino acids, with Lamin C differing only in 6 unique carboxy-terminal amino acids.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Lamin A (D230) polyclonal antibody detects endogenous levels of Lamin A protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Prelamin-A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1

Immunogen :Synthetic peptide, corresponding Human Cleaved-Lamin A.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Cleaved-Lamin A (D230) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:The Lung tissue lysate of Mouse(40ug) Lane4:The Spleen tissue lysate of Rat(40ug)

Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation

JournalPharmacological Research

ApplicationWB

IF7.658

SpeciesMouse

PMID24788079
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway

JournalVascular Pharmacology

ApplicationWB

IF4.152

SpeciesHuman

PMID
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells

JournalFree Radical Research

ApplicationWB

IF4.148

SpeciesHuman

PMID
Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming

JournalAntioxidants & Redox Signaling

ApplicationWB

IF5.828

SpeciesHuman

PMID27308893
Malignant gliomas induce and exploit astrocytic mesenchymal-like transition by activating canonical Wnt/β-catenin signaling

JournalMedical Oncology

ApplicationWB

IF3.252

SpeciesRat

PMID