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CXCR-3 polyclonal antibody

货号: BS6993

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS6993

Product Name :CXCR-3 polyclonal antibody

Swiss-Prot :P49682

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC

Application_all :WB 1:500 - 1:1000 IHC 1:50 - 1:200

Background :The CXC or a chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemo-attractants for neutrophils. The CXC family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the CXC family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB, CXCR-3 and fusin (variously referred to as LESTR or CXCR-4). CXCR-3, also known as IP-10/Mig receptor, mediates Ca++ mobilization and chemotaxis in response to the CXC chemo-kines IP-10 and Mig. CXCR-3 is highly expressed in IL-2-activated T lymphocytes, but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CXCR-3 polyclonal antibody detects endogenous levels of CXCR-3 protein.

BiowMW :~ 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183; GPR9; CXCR3

Immunogen :Synthetic peptide, corresponding to Human CXCR-3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CXCR-3 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate(40ug) LaneB:Hela whole cell lysate(40ug) LaneC:The Heart tissue lysate of Mouse(40ug) LaneD:The Kidney tissue lysate of Mouse(40ug)

Immunohistochemical analysis of CD183 staining in human muscle formalin fixed paraffin embedded tissue section.