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IRF3 polyclonal antibody

货号: BS6921

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6921

Product Name :IRF3 polyclonal antibody

Swiss-Prot :Q14653

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB 1:500 - 1:1000 IHC 1:100 - 1:200 IF1:100 - 1:500

Background :IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRF3 polyclonal antibody detects endogenous levels of IRF3 protein.

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,STING Signaling,Toll-like Receptor signaling,

Alternative Name :Interferon regulatory factor 3; IRF-3

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IRF3.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of IRF3 expression in PC3 (A), mouse brain (B), rat brain (C) whole cell lysates.

Immunohistochemical analysis of IRF3 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of IRF3 staining in HeLa cells.

Autophagy-Mediated Clearance of Free Genomic DNA in the Cytoplasm Protects the Growth and Survival of Cancer Cells

JournalFrontiers in Oncology

ApplicationWB,IF

IF6.244

SpeciesHuman

PMID34123836
Akt phosphorylation regulated by IKKε in response to low shear stress leads to endothelial inflammation via activating IRF3

JournalCellular Signalling

ApplicationWB

IF3.968

SpeciesHuman

PMID33370582