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NQO1 polyclonal antibody

货号: BS6833

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6833

Product Name :NQO1 polyclonal antibody

Swiss-Prot :P15559

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100|IF/ICC,1:50 - 1:100

Background :This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NQO1 polyclonal antibody detects endogenous levels of NQO1 protein.

BiowMW :31KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DHQU;DIA4;DTD;NMOR1;NMORI;QR1;NQO1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NQO1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of NQO1 expression in HEK293T (A), Hela (B), A2788 (C), H460 (D), HepG2 (E), mouse kidney (F), rat kidney (G) whole cell lysates.

Immunohistochemical analysis of NQO1 staining in rat heart formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of NQO1 staining in BV2 cells.

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SpeciesMouse

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GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

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IF3.998

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Regulation of PKM2 and Nrf2-ARE Pathway during Benzoquinone Induced Oxidative Stress in Yolk Sac Hematopoietic Stem Cells

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IF2.74

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Remote limb ischemic postconditioning protects mouse brain against cerebral ischemia/reperfusion injury via upregulating expression of Nrf2, HO-1 and NQO-1 in mice

JournalInternational Journal Of Neuroscience

ApplicationIHC,WB

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PMID26000916
Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy

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