Product Name :Collagen 1 alpha 1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, IF/ICC, IP
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200), IP (1/50 - 1/100)
Background :Type 1 collagen is the most abundant collagen in many human tissues, including bone, skin, and tendons. It is a trimeric complex comprised of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen). The expression levels of COL1A1 are regulated by multiple mechanisms, including mRNA stability, translation, and posttranslational modification. Overexpression of COL1A1 has been positively associated with tissue fibrosis disorders, including systemic sclerosis, while loss-of-function mutations in the COL1A1 gene are a major causative factor for osteogenesis imperfecta (brittle bone disease). Notably, COL1A1 expression levels have also been associated with tumor development in gastric, lung, thyroid, and breast cancers. Research studies suggest that upregulation of COL1A1 can generate a modified extracellular matrix environment that promotes cancer cell survival, proliferation, metastasis, and invasion.
Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of Collagen 1 alpha 1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Collagen alpha-1(I) chain; Alpha-1 type I collagen
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence of human Collagen 1 alpha 1. The exact sequence is proprietary.
Modification :Unmodification
