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SGK1 (Phospho-T256) polyclonal antibody

货号: BS67593

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67593

Product Name :SGK1 (Phospho-T256) polyclonal antibody

Swiss-Prot :O00141

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt . SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways . Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation . SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion . SGK is negatively regulated by ubiquitination and proteasome degradation .

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SGK1 with a phosphorylation site at T256 protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :MTOR signaling

Alternative Name :SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SGK1 with a phosphorylation site at T256. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot analysis of SGK1 (pT256) expression in rat liver (A), mouse brain (B) whole cell lysates.