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GPx-4 polyclonal antibody

货号: BS67575

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67575

Product Name :GPx-4 polyclonal antibody

Swiss-Prot :P36969

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation . GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis . Research studies show that selenium enhances GPX4 expression and inhibits ferroptotic death to protect neurons . In addition, some therapy-resistant cancer cells depend on GPX4 to survive. Loss of GPX4 leads to ferroptosis and thus prevents tumor relapse in mice . Furthermore, redox homeostasis mediated by GPX4 is essential for activation of the cytosolic DNA-sensing cGAS-STING pathway and initiation of the subsequent innate immune response .

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GPx-4 protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Phospholipid hydroperoxide glutathione peroxidase mitochondrial; PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPx-4. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GPx-4 expression in HEK293T (A), K562 (B) whole cell lysates.

免疫沉淀（IP）