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PTEN (AcK402) polyclonal antibody

货号: BS67564

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67564

Product Name :PTEN (AcK402) polyclonal antibody

Swiss-Prot :P60484

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K). PTEN is a major negative regulator of the PI3K/Akt signaling pathway . PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity . PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis.

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PTEN with an acetylation site at K402 protein.

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inhibition of Apoptosis，Regulation of Microtubule Dynamics，PI3K AKT signaling，MTOR signaling

Alternative Name :MMAC1; TEP1; Phosphatidylinositol 345-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PTEN with an acetylation site at K402. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PTEN (AcK402) expression in HEK293T (A), mouse spleen (B) whole cell lysates.