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Histone H2A.Z (AcK13) polyclonal antibody

货号: BS67559

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS67559

Product Name :Histone H2A.Z (AcK13) polyclonal antibody

Swiss-Prot :P0C0S5

Host :Rabbit

Reactivity :Human, Zebrafish

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Modulation of chromatin structure plays a critical role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure . There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z . Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability . Several homologous protein complexes, such as SWR-C (S. cerevisiae), TIP60 (D. melanogaster) and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This exchange of histone H2A variants changes histone-histone interactions in the nucleosome core and alters an acidic patch on the surface of the nucleosome, resulting in changes in nucleosome stability and binding of non-histone proteins such as HP1α .

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Histone H2A.Z with an acetylation site at K13 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :H2AZ; Histone H2A.Z; H2A/z

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone H2A.Z with an acetylation site at K13. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Histone H2A.Z (AcK13) expression in zebrafish (A) whole cell lysates.