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CIITA polyclonal antibody

货号: BS67513

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :BS67513

Product Name :CIITA polyclonal antibody

Swiss-Prot :P33076

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :MHC class II (MHC-II) proteins play critical roles in cellular immune responses and their expression is mainly regulated by the non-DNA binding transcription factor CIITA (MHC class II transactivator) . CIITA expression is upregulated by IFN-γ and it in turn enchances MHC-II expression and represses collagen expression . CIITA has a limited number of transcriptional targets, most of which are involved in MHC-mediated antigen presentation . Mutations in the CIITA are associated with the hereditary immunodeficiency disease Bare Lymphocyte Syndrome (BLS) which is characterized by a nearly complete absence of MHC-II expression (also referred to as MHC-II deficiency).

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CIITA protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MHC2TA; MHC class II transactivator; CIITA

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CIITA expression in Beas2B (A), Jurkat (B) whole cell lysates.

免疫沉淀（IP）