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Cathepsin B polyclonal antibody

货号: BS67486

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS67486

Product Name :Cathepsin B polyclonal antibody

Swiss-Prot :P07858

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Cathepsin B (CSTB), part of the papain family of proteases, is a widely expressed lysosomal cysteine endopeptidase . Cathepsin B is produced from a larger precursor form, pro-cathepsin B, which runs at approximately 44 kDa on SDS-PAGE, and is proteolytically processed and glycosylated to form a mature two-chain protein containing a heavy chain (running at 27 and 24 kDa) and a light chain (5 kDa). High levels of cathepsin B are found in macrophages and osteoclasts, as well as various types of cancer cells, including lung, colon, prostate, breast, and stomach. In addition, expression of cathepsin B has been associated with multiple sclerosis , rheumatoid arthritis , and pancreatitis . While generally localized to lysosomes, in cancer alterations can lead to its secretion . Its role in tumor progression is thought to involve promotion of basement membrane degradation, invasion and metastasis. Expression can correlate with poor prognosis for a variety of forms of cancer .

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Cathepsin B protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin B. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Cathepsin B expression in mouse embryo (A), rat lung (B), HCT116 (C), A549 (D) whole cell lysates.