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Paxillin polyclonal antibody

货号: BS67453

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67453

Product Name :Paxillin polyclonal antibody

Swiss-Prot :P49023

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix . Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization . Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 . Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Paxillin protein.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics，ErbB HER Signaling，MAPK Erk in Growth and Differentiation Pathway(，PI3K AKT signaling.

Alternative Name :Paxillin

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Paxillin. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Paxillin expression in U87MG (A) whole cell lysates.