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MKK1/2 polyclonal antibody

货号: BS67451

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS67451

Product Name :MKK1/2 polyclonal antibody

Swiss-Prot :Q02750; P36507

Host :Rabbit

Reactivity :Human, Mouse, Rat, Chicken, Dog, Zebrafish

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx . Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells . MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of MKK1/2 protein.

BiowMW :~ 37 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics，ESC Pluripotency and Differentiation Signaling Pathway，ErbB HER Signaling，G Protein-coupled Receptors Signaling to MAPK Erk，MAPK Erk in Growth and Differentiation Pathway(，Jak Stat ：IL-6 Receptor Signaling，T cell receptor signaling，Warburg Effect.

Alternative Name :MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MKK1/2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of MKK1/2 expression in mouse lung (A), mouse kidney (B), rat lung (C), rat kidney (D) whole cell lysates.