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STAT2 polyclonal antibody

货号: BS67421

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67421

Product Name :STAT2 polyclonal antibody

Swiss-Prot :P52630

Host :Rabbit

Reactivity :Human, Mouse, Rat, Pig

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Stat2 (113-kDa), originally purified from the nuclei of alpha-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via associations with receptor-bound Jak kinases. Unlike other Stat proteins, Stat2 does not form homodimers. Instead, activated Stat2 forms a heterodimer with Stat1 and translocates to the nucleus. There, it associates with the DNA-binding protein p48 and forms the transcriptional activator complex, interferon-stimulated gene factor 3 (ISGF3), promoting transcription from the ISRE.

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of STAT2 protein.

BiowMW :~ 113 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Signal transducer and activator of transcription 2; p113

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human STAT2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of STAT2 expression in mouse muscle (A), rat muscle (B) whole cell lysates.

免疫沉淀（IP）