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PI3K p85 beta polyclonal antibody

货号: BS67364

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS67364

Product Name :PI3K p85 beta polyclonal antibody

Swiss-Prot :O00459

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy.

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of PI3K p85 beta protein.

BiowMW :~ 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling.

Alternative Name :Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PI3K p85 beta. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PI3K p85 beta expression in A549 (A), LO2 (B), BV2 (C), SGC7901 (D), PC12 (E) whole cell lysates.