产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Axin-2 polyclonal antibody

货号: BS67312

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS67312

Product Name :Axin-2 polyclonal antibody

Swiss-Prot :Q9Y2T1

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/2000), IF/ICC (1/50 - 1/200)

Background :Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin . Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling . In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) . Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice . Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop .

Product :Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Axin-2 protein.

BiowMW :~ 91 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ESC Pluripotency and Differentiation Signaling Pathway,Wntβ catenin signaling,

Alternative Name :Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin

Immunogen :Recombinant full length protein of human Axin-2

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Axin-2 expression in mouse lung (A), mouse brain (B), mouse liver (C) whole cell lysates.

免疫沉淀（IP）

免疫组织化学（IHC）