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PGK1 polyclonal antibody

货号: BS6691

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6691

Product Name :PGK1 polyclonal antibody

Swiss-Prot :P00558

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IH: 1:50~1:200

Background :Phosphoglycerate kinases 1/2 (PGK1/2, ATP:3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) are somatically expressed, glycolytic enzymes that catalyze the transfer of a phosphoryl group from the acyl phosphate of 1,3-bisphosphoglycerate to ADP, thereby forming ATP and 3-phosphoglycerate. The human PGK gene is interrupted by 10 introns and spans 23 kilobases, and is X chromosome-linked at position Xq21.1, a region implicated in prostate cancer, androgen insensitivity, perineal hypospadias, and other genetic abnormalities. In addition to influencing glycolysis, the PGK1 is secreted by tumor cells and contributes to proliferative angiogenic processes as a disulfide reductase. PGK1 mediated reduction of disulphide bonds in the serine proteinase plasmin initiates the release of the tumor blood vessel inhibitor angiostatin, an event that is critical for blood vessel formation or angiogenesis in tumor expansion and metastasis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PGK1 polyclonal antibody detects endogenous levels of PGK1 protein.

BiowMW :~ 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell migration-inducing gene 10 protein; MGC117307; MGC8947; MIG10; pgk1; PGK1; PGKA; Phosphoglycerate kinase 1; Primer recognition protein 2; PRP 2; PRP 2;

Immunogen :Recombinant full length Human PGK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PGK1 expression in Hela (A), PC3 (B), ES2 (C), mouse stomach (D) whole cell lysates.

Immunohistochemical analysis of PGK1 staining in human colon formalin fixed paraffin embedded tissue section.