Product Name :IL-10 (3-8) monoclonal antibody
Reactivity :Human,Rat,Mouse
Application_all :WB: 1:1000~1:2000
Background :The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Product :Mouse IgG, 0.6mg/ml in PBS with 0.05% Proclin300, 50% glycerol, 0.2% BSA, pH7.2.
Purification&Purity :The antibody was affinity-purified from cell culture supernatant by protein A+G and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :IL-10 (3-8) monoclonal antibody detects endogenous levels of IL-10 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :IL-10; Cytokine synthesis inhibitory factor (CSIF); Interleukin-10
Immunogen :Recombinant protein of human IL-10.
