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ATM polyclonal antibody

货号: BS66236

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS66236

Product Name :ATM polyclonal antibody

Swiss-Prot :Q13315

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB IHC

Application_all :WB 1:500 - 1:1000 IHC 1:100 - 1:200

Background :The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ATM polyclonal antibody detects endogenous levels of ATM protein.

BiowMW :~ 350 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ATM.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of ATM expression in K562 (A), mouse brain (B) whole cell lysates.

Immunohistochemical analysis of ATM staining in human prostate cancer formalin fixed paraffin embedded tissue section.

免疫沉淀（IP）

免疫组织化学（IHC）