Product Name :ABCA1 polyclonal antibody
Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200
Background :The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ABCA1 polyclonal antibody detects endogenous levels of ABCA1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13; ABCA1
Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2).
