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CHRDL1 polyclonal antibody

货号: BS66188

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS66188

Product Name :CHRDL1 polyclonal antibody

Swiss-Prot :Q9BU40

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC-P

Application_all :WB: 1:500-1:1000 IHC-P: 1:50-1:100

Background :The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :P Glycoprotein polyclonal antibody detects endogenous levels of P Glycoprotein protein.

BiowMW :180KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ABC20;CD243;CLCS;GP170;MDR1;P-GP;PGY1;P Glycoprotein;ABCB1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human P Glycoprotein.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of P Glycoprotein expression in C6 (A), DLD (B), BV2 (C) whole cell lysates.

Immunohistochemical analysis of P Glycoprotein staining in human brain formalin fixed paraffin embedded tissue section.

免疫沉淀（IP）

免疫组织化学（IHC）