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APC polyclonal antibody

货号: BS66127

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS66127

Product Name :APC polyclonal antibody

Swiss-Prot :P25054

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF/ICC IHC

Application_all :WB 1:500 - 1:2000 IF/ICC 1:10 - 1:100 IHC 1:50 - 1:200

Background :This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :APC polyclonal antibody detects endogenous levels of APC protein.

BiowMW :~ 150 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Contribution of Soluble Factors to EMT,

Alternative Name :APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_000029.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using APC antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded human lung using APC antibody at dilution of 1:200 (40x lens).

Immunohistochemistry of paraffin-embedded human colon using APC antibody at dilution of 1:200 (40x lens).