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NCOA4 polyclonal antibody

货号: BS66112

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS66112

Product Name :NCOA4 polyclonal antibody

Swiss-Prot :Q13772

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500-1:1000 IHC: 1:50-1:100

Background :Nuclear Receptor Coactivator 4 (NCOA4), also known as ARA70 or ELE1, was initially discovered as a transcriptional coactivator of androgen receptor. NCOA4 has also been implicated in regulation of peroxisome proliferator-activated receptor gamma and alpha, as well as estrogen receptor alpha. NCOA4 plays an autophagic role as a cargo receptor by shuttling ferritin to the lysosome in order to maintain iron homeostasis, which ultimately controls heme synthesis and red blood cell development. The NCOA4 gene has been shown to undergo a fusion event with the RET proto-oncogene, forming RET/PTC3 in thyroid and other types of cancers.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NCOA4 polyclonal antibody detects endogenous levels of NCOA4 protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :NF-kB Signaling,NF-kB Signaling,Immune Cell Signaling,Signaling Pathways Activating p38 MAP KinaseSTING Signaling,T cell receptor signaling,Inhibition of Apoptosis,Contribution of Soluble Factors to EMT,

Alternative Name :ARA70; ELE1; RFG; Nuclear receptor coactivator 4; NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NCOA4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of NCOA4 expression in H1688 (A) whole cell lysates.

Immunohistochemical analysis of NCOA4 staining in human breast cancer formalin fixed paraffin embedded tissue section.