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PERK (Phospho-Thr982) polyclonal antibody

货号: BS66100

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS66100

Product Name :PERK (Phospho-Thr982) polyclonal antibody

Swiss-Prot :Q9NZJ5

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC

Application_all :WB 1:500 - 1:1000 IHC 1:100 - 1:200

Background :The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PERK (Phospho-Thr980) polyclonal antibody detects endogenous levels of PERK protein only when phosphorylated at Thr980.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Translational Contral Regulation of elF2,

Alternative Name :p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PERK.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of PERK (pT982) expression in A375 (A), MCF7 (B), mouse testis (C) whole cell lysates.

Immunohistochemical analysis of PERK (pT982) staining in human lung cancer formalin fixed paraffin embedded tissue section.

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