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CHMP4B+CHMP4C Polyclonal Antibody

货号: BS65990

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS65990

Product Name :CHMP4B+CHMP4C Polyclonal Antibody

Swiss-Prot :Q9H444, Q96CF2

Host :Rabbit

Reactivity :Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CHMP4B+CHMP4C Polyclonal Antibody detects endogenous levels of CHMP4B+CHMP4C protein.

BiowMW :25kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SNF7 homolog associated with Alix 3; C20orf178; Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP 4B; CHMP 4C; CHMP4A; Chromatin modifying protein 4B; Chromatin modifying protein 4C; CTPP3; dJ553F4.4; hSnf7 2; hSnf7 3; hVps32; MGC22825; Shax1; Shax3; SNF7 2; SNF7 3; SNF7; Snf7 homologue associated with Alix 1; Vacuolar protein sorting associated protein 7 2; Vacuolar protein sorting associated protein 7 3.

Immunogen :KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C:101-200/224

Conjugate :Unconjugated

Modification :Unmodification

Paraformaldehyde-fixed, paraffin embedded (rat lung tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CHMP4B+CHMP4C) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CHMP4B+CHMP4C) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C,