Product Name :phospho-MCK10 (Tyr513) Polyclonal Antibody
Reactivity :Human,Mouse,Rat,Pig,Cow,Horse,
Application_all :IHC-P=1:100-500
Background :Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :phospho-MCK10 (Tyr513) Polyclonal Antibody detects endogenous levels of MCK10 protein only when phosphorylated at Tyr513.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :MCK10 (phospho Y513); p-MCK10 (phospho Y513); CAK; CD167a; DDR1CD 167; CD167; Cell adhesion kinase; DDR 1; DDR; DDR1; Discoidin domain receptor; Discoidin receptor tyrosine kinase isoform a; EDDR 1; Epithelial discoidin domain receptor 1; Epithelial specific receptor kinase; Mammarian carcinoma kinase 10; Neuroepithelial tyrosine kinase; Neurotrophic tyrosine kinase receptor type 4; NTRK 4; PTK 3; PTK 3A protein tyrosine kinase 3A; Receptor tyrosine kinase NEP; RTK 6; TRK E; Tyrosine kinase receptor E; DDR1_HUMAN.
Immunogen :KLH conjugated synthesised phosphopeptide derived from human MCK10 around the phosphorylation site of Tyr513:PA(p-Y)RL
Modification :Phosphorylation
