Product Name :Phospho-LRP6 (Thr1479)Polyclonal Antibody
Reactivity :Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,
Application_all :Flow-Cyt=0.2ug/test
Background :This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Phospho-LRP6 (Thr1479) Polyclonal Antibody detects endogenous levels of LRP6 protein only when phosphorylated at Thr1479.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Microtubule Dynamics,
Alternative Name :LRP6 (Phospho-Thr1479); LRP6 (Phospho-T1479); p-LRP6 (Thr1479); p-LRP6 (T1479); ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6.
Immunogen :KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG(p-T)YF <Cytoplasmic>
Modification :Phosphorylation
