Product Name :phospho-AKT3 (Ser472) Polyclonal Antibody
Reactivity :Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep,
Application_all :WB=1:500-2000
Background :Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase (PI 3 kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). IGF1 leads to the activation of AKT3, which may play a role in regulating cell survival. It is capable of phosphorylating several known proteins.
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :phospho-AKT3 (Ser472) Polyclonal Antibody detects endogenous levels of AKT3 protein only when phosphorylated at Ser472.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phosphoinosotode Signaling,Immune Cell Signaling,Warburg Effect,Translational Contral elF4 and p70 S6 Kinase,Insulin &Glucose Signaling,ErbB HER Signaling,
Alternative Name :Akt3; AKT3 kinase; AKT3_HUMAN; DKFZp434N0250; PKB gamma; PKBG; PRKBG; Protein kinase Akt-3; Protein Kinase AKT3; Protein kinase B gamma; RAC gamma; RAC gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; RACPK Gamma; Serine threonine protein kinase Akt 3; Serine threonine protein kinase Akt3; STK 2; STK-2; STK2; V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma.
Immunogen :KLH conjugated Synthesised phosphopeptide derived from human AKT3 around the phosphorylation site of Ser472:QF(p-S)YS
Modification :Phosphorylation
