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PER2/Period circadian protein 2 Polyclonal Antibody

货号: BS65878

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS65878

Product Name :PER2/Period circadian protein 2 Polyclonal Antibody

Swiss-Prot :O15055

Host :Rabbit

Reactivity :Human,Mouse,Rat,Dog,Cow,Horse,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :PER2, a mammalian homologue of the Drosophila period gene, shares a 40% homology with PER1 including the protein dimerization PAS domain. PER2 is a circadian regulator that may act as a transcription factor. It behaves as a negative element in circadian transcriptional loop. PER2 does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (SCN) and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -51°C long term. Avoid freeze-thaw cycles.

Specificity :PER2/Period circadian protein 2 Polyclonal Antibody detects endogenous levels of PER2/Period circadian protein 2 protein.

BiowMW :~138 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Circadian clock protein PERIOD 2; FASPS; hPER 2; hPER2; KIAA0347; PER 2; PER2; Period 2; Period 2 isoform 1; Period circadian protein 2; Period circadian protein homolog 2; Period homolog 2; Period2; FASPS; PER2_HUMAN.

Immunogen :KLH conjugated synthetic peptide derived from human PER2:751-850/1225

Conjugate :Unconjugated

Modification :Unmodification

Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PER2) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

Paraformaldehyde-fixed, paraffin embedded (Rat skeletal muscle); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PER2) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C