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CREB-1 Polyclonal Antibody

货号: BS65863

价格：￥ ——

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65863

Product Name :CREB-1 Polyclonal Antibody

Swiss-Prot :P16220

Host :Rabbit

Reactivity :Human,Mouse,Rat,

Applications :WB,

Application_all :WB=1:500-2000

Background :Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -36°C long term. Avoid freeze-thaw cycles.

Specificity :CREB-1 Polyclonal Antibody detects endogenous levels of CREB-1 protein.

BiowMW :~47 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB; CREB1_HUMAN.

Immunogen :KLH conjugated synthetic peptide derived from human CREB-1:51-120/341

Conjugate :Unconjugated

Modification :Unmodification

Primary: Anti-CREB-1 at 1/300 dilution

Primary: Anti-CREB-1 at 1/1000 dilution