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Caspase-1 P10 Polyclonal Antibody

货号: BS65859

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65859

Product Name :Caspase-1 P10 Polyclonal Antibody

Swiss-Prot :P29452

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC

Application_all :WB: 1:500-1:2000 IHC: 1:50-1:200

Background :This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -32°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Caspase 1 protein.

BiowMW :~10-55 kDa kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :caspase-1 isoform alpha p10 subunit; CASP 1; CASP1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; ICE; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BC; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme. CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; Caspase-1 subunit p10.

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Caspase 1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Caspase 1 expression in H1792 (A), MCF7 (B), Hela (C), mouse spleen (D), mouse lung (E), rat spleen (F) whole cell lysates.

Immunohistochemical analysis of Caspase 1 staining in human skin formalin fixed paraffin embedded tissue section.