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SKOR2 Polyclonal Antibody

货号: BS65800

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS65800

Product Name :SKOR2 Polyclonal Antibody

Swiss-Prot :Q2VWA4

Host :Rabbit

Reactivity :Human,Mouse,Rat,Dog,Cow,Sheep,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-尾 by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-尾 in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles.

Specificity :SKOR2 Polyclonal Antibody detects endogenous levels of SKOR2 protein.

BiowMW :~104 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN

Immunogen :KLH conjugated synthetic peptide derived from human SKOR2:871-970/100

Conjugate :Unconjugated

Modification :Unmodification

Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SKOR2) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

Paraformaldehyde-fixed, paraffin embedded (rat spinal cord tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SKOR2) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C