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phospho-Androgen Receptor (Ser515) Polyclonal Antibody

货号: BS65726

价格：￥ ——

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS65726

Product Name :phospho-Androgen Receptor (Ser515) Polyclonal Antibody

Swiss-Prot :P10275

Host :Rabbit

Reactivity :Human,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :phospho-Androgen Receptor (Ser515) Polyclonal Antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser515.

BiowMW :99kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,

Alternative Name :Androgen Receptor (phospho S515); Androgen Receptor (Phospho-Ser515); Androgen Receptor (phospho Ser515); p-Androgen Receptor (Ser515); ANDR_HUMAN; HYSP1; AIS; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); AR; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal and bulbar muscular atrophy; TFM.

Immunogen :KLH conjugated synthesised phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser515 :YP(p-S)PT

Conjugate :Unconjugated

Modification :Phosphorylation

Paraformaldehyde-fixed, paraffin embedded (human prostate tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Androgen Receptor (Ser515)) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Androgen Receptor (Ser515)) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C