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PCP4 Polyclonal Antibody

货号: BS65683

价格：￥ ——

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65683

Product Name :PCP4 Polyclonal Antibody

Swiss-Prot :P48539

Host :Rabbit

Reactivity :Human,Mouse,Rat,Cow,Sheep,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PCP4 Polyclonal Antibody detects endogenous levels of PCP4 protein.

BiowMW :7kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19.

Immunogen :KLH conjugated synthetic peptide derived from human PCP4

Conjugate :Unconjugated

Modification :Unmodification

Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PCP4) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C