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Ataxin 7 Polyclonal Antibody

货号: BS65680

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS65680

Product Name :Ataxin 7 Polyclonal Antibody

Swiss-Prot :O15265

Host :Rabbit

Reactivity :Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ataxin 7 Polyclonal Antibody detects endogenous levels of Ataxin 7 protein.

BiowMW :95kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ataxin7; Ataxin-7; ADCAII; ATXN 7; OPCA III; OPCA3; SCA 7; SCA7; Spinocerebellar Ataxia 7; Spinocerebellar ataxia type 7 protein; ATX7_HUMAN.

Immunogen :KLH conjugated synthetic peptide derived from human Ataxin 7

Conjugate :Unconjugated

Modification :Unmodification

Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ataxin 7) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C