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Caspase-12 Polyclonal Antibody

货号: BS65665

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65665

Product Name :Caspase-12 Polyclonal Antibody

Swiss-Prot :O08736

Host :Rabbit

Reactivity :Mouse,Rat,

Applications :WB,

Application_all :WB=1:500-2000

Background :Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caspase-12 Polyclonal Antibody detects endogenous levels of Caspase-12 protein.

BiowMW :46 kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.

Immunogen :KLH conjugated synthetic peptide derived from the middle of human Caspase-12

Conjugate :Unconjugated

Modification :Unmodification

Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebrum (Rat) Lysate at 40 ug Primary: Anti-alpha smooth muscle Actin at 1/300 dilution

Sample: Lane 1: Muscle (Mouse) Tissue Lysate at 40 ug Lane 2: Muscle (Rat) Tissue Lysate at 40 ug Primary: Anti-Caspase-12 at 1/1000 dilution

YiQiFuMai Powder Injection Ameliorates Cerebral Ischemia by Inhibiting Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis

JournalOxidative Medicine and Cellular Longevity

ApplicationWB

IF6.543

SpeciesMouse

PMID27087890
Asiatic Acid Alleviates LPS-Induced Pyroptosis and Endoplasmic Reticulum Stress-Mediated Apoptosis via Inhibiting the HMGB1/TLR4/NF-κB Pathway in Broiler Hepatocytes

Journal10.1111/jpn.14070

ApplicationWB

IF2.2

SpeciesChicken

PMID39543935