产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Caspase-1 p20 Polyclonal Antibody

货号: BS65650

价格：￥ ——

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65650

Product Name :Caspase-1 p20 Polyclonal Antibody

Swiss-Prot :P29466

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF ICC ELISA

Application_all :WB 1:500 - 1:2000 IHC 1:100 - 1:500 IF 1:100 - 1:500 ICC 1:100 - 1:500 ELISA 1:5000 - 1:10000

Background :This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caspase-1 p20 Polyclonal Antibody detects endogenous levels of Caspase-1 p20 protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :caspase-1 isoform alpha p20 subunit; CASP1; ICE; IL1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45

Immunogen :KLH conjugated synthetic peptide derived from mouse Caspase-1 p20

Conjugate :Unconjugated

Modification :Unmodification

Primary: Anti-Caspase-1 p20 at 1/1000 dilution.

Tissue/cell: Mouse spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer at 37℃ for 20 min; Incubation: Anti-Caspase-1 p20 Polyclonal Antibody, Unconjugated 1:500, overnight at 4℃.

Ketone Metabolite β-Hydroxybutyrate Ameliorates Inflammation After Spinal Cord Injury by Inhibiting the NLRP3 Inflammasome

JournalNeurochemical Research

ApplicationWB

IF3.038

SpeciesRat

PMID33108630
Total astragalosides decrease apoptosis and pyroptosis by inhibiting enterovirus 71 replication in gastric epithelial cells

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF2.447

SpeciesHuman

PMID
Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis

JournalARTHRITIS RESEARCH & THERAPY

ApplicationWB,IHC

IF5.156

SpeciesRat

PMID35585627
The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis

JournalJournal of Orthopaedic Translation

ApplicationIHC

IF6.6

SpeciesHuman

PMID