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CD86 Polyclonal Antibody

货号: BS65646

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS65646

Product Name :CD86 Polyclonal Antibody

Swiss-Prot :P42081

Host :Rabbit

Reactivity :Human,Mouse,Rat,

Applications :WB IF/ICC IP

Application_all :WB: 1:100-1:500 IF/ICC: 1:50-1:200 IP: 1:50-1:200

Background :This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD86 Polyclonal Antibody detects endogenous levels of CD86 protein.

BiowMW :~ 65-70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD28LG2; FUN1; LAB72; Activation B7 2 antigen; Activation B7-2 antigen 3; CD86_HUMAN; Activation B7-2 antigen; Activation B72 antigen; B lymphocyte activation antigen B7 2; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7 2 antigen; B7; B7-2; B7.2; B70; B72 antigen; BU63; CD 86; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2; CD86 antigen; CD86 molecule; CLS1; CTLA 4 counter receptor B7 2; CTLA 4 counter receptor B7.2; CTLA-4 counter-receptor B7.2 2, 3; CTLA4 counter receptor B72; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein; MGC34413; T lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; TS/A-2

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human CD86 (NP_787058.4).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of extracts of various cell lines, using CD86 antibody at 1:500 dilution.

Immunofluorescence analysis of THP-1 cells using CD86 Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunofluorescence analysis of rat spleen using CD86 Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunoprecipitation analysis of 200 μg extracts of Jurkat cells using 3 μg CD86 antibody. Western blot was performed from the immunoprecipitate using CD86 antibody at a dilution of 1:1000.

Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway

JournalNeuroscience

ApplicationIF

IF3.056

SpeciesMouse

PMID31726033